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Publications (Last 5 years)

2024

  1. Badger-Emeka, L.; Emeka, P.; Thirugnanasambantham, K*.; Alatawi, A.S. The Role ofPseudomonas aeruginosain the Pathogenesis of Corneal Ulcer, Its Associated Virulence Factors, and Suggested Novel Treatment Approaches.Pharmaceutics 2024,16, 1074. https://doi.org/10.3390/pharmaceutics16081074

  2. Ashokkumar V, Thirugnanasambantham K, Palanisamy S (2024). Unveiling UVB resilience in Oryza sativa L.: Integrative analysis of physiological, molecular and microRNA responses,Plant Stress,Volume 12,100495, https://doi.org/10.1016/j.stress.2024.100495.

  3. Abdullah Sheikh, Hairul Islam Mohamed Ibrahim, Faisal Almathen, Mohammed Alfattah, Ashraf Khalifa,Beneficial probiotic bacteria prevalence in different lactating dromedary camel milk of Saudi Arabia,Saudi Journal of Biological Sciences,  31(1),2024,103879,Ihttps://doi.org/10.1016/j.sjbs.2023.103879.

  4. Hassanin HA, Taha A, Ibrahim H-IM, Ahmed EA, Mohamed H and Ahmed H (2024) Cytotoxic activity of bimetallic Ag@Se green synthesized nanoparticles using Jerusalem Thorn (Parkinsonia aculeata). Front. Chem. 12:1343506. doi: 10.3389/fchem.2024.1343506

  5. Ahmed, E.A., Alzahrani, A.M., Abdelsalam, S.A.and Hairul-Islam M. Ibrahim. Flavipin from fungi as a potential inhibitor of rheumatoid arthritis signaling molecules. Inflammopharmacol 32, 1171–1186 (2024). https://doi.org/10.1007/s10787-024-01429-8

2023

  1. Ibrahim, H.I.M.; Sheikh, A.; Khalil, H.E.; Khalifa, A. Bacillus amyloliquifaciens-Supplemented Camel Milk Suppresses Neuroinflammation of Autoimmune Encephalomyelitis in a Mouse Model by Regulating Inflammatory Markers. Nutrients 2023, 15, 550. https://doi.org/10.3390/nu15030550

  2. Khalil HA., Ibrahim MIH., Thirugnanasambantham K. Rectal gel loaded with Date palm phenolics and vanillic acid?; novel therapy strategy for ?the treatment of irritable bowel syndrome. US Patent; Patent number -11806430; date - 2023/11/7

  3. Bharanidharan R*, Thirugnanasambantham T*, Kim J, Xaysana P, et al.,, Supplementation with rumen-inert fat in the growing phase altered adipogenic gene expression and the size and number of adipocytes in Hanwoo steers, Journal of Animal Science, Volume 101, 2023, skad315, https://doi.org/10.1093/jas/skad315

  4. Khalifa, A.; Ibrahim, H.-I.M.; Sheikh, A.; Khalil, H.E. Attenuation of Immunogenicity in MOG-Induced Oligodendrocytes by the Probiotic Bacterium Lactococcus Sp. PO3. Medicina 2023, 59, 1731. https://doi.org/10.3390/medicina59101731

  5. Alsaud, N.; Almajed, A.; Lwusaybie, A.; Alsubaie, A.; Alobaidan, H.; Alessa, J.; Almousa, A.; Ibrahim, H.I.M.; Khalifa, A. The Halotolerant Probiotic Bacterium Enterococcus lactis ASF-2 from Al-Asfar Lake, Saudi Arabia, Reduces Inflammation in Carrageenan-Induced Paw Edema. Microorganisms 2023, 11, 2415. https://doi.org/10.3390/microorganisms11102415

  6. Khalifa, A.; Ibrahim, H.-I.M.; Sheikh, A. Bacillus subtilis PM5 from Camel Milk Boosts Chicken Immunity and Abrogates Salmonella entertitidis Infections. Microorganisms 2023, 11, 1719. https://doi.org/10.3390/microorganisms11071719

  7. Akshaya1, BS, Premraj, K, Iswarya, C, Muthusamy S, Ibrahim, HIM, Khalil, HE,  Gunasekaran, V, Vickram, S, Senthil Kumar, V, Palanisamy S*, and Thirugnanasambantham K* (2023). Cinnamaldehyde inhibits Enterococcus faecalis biofilm formation and promotes clearance of its colonization by modulation of phagocytes in vitro. Microbial Pathogenesis, 181: 106157. https://doi.org/10.1016/j.micpath.2023.106157

  8. Khalifa, A.; Ibrahim, H.I.M.; Sheikh, A.; Khalil, H.E. Probiotic-Fermented Camel Milk Attenuates Neurodegenerative Symptoms via SOX5/miR-218 Axis Orchestration in Mouse Models. Pharmaceuticals 2023, 16, 357. https://doi.org/10.3390/ph16030357

  9. Ibrahim HIM, Sheikh A, Khalil HE, Khalifa A. Bacillus amyloliquifaciens-Supplemented Camel Milk Suppresses Neuroinflammation of Autoimmune Encephalomyelitis in a Mouse Model by Regulating Inflammatory Markers. Nutrients. 2023; 15(3):550. https://doi.org/10.3390/nu15030550

  10. Ashraf Khalifa , Hairul Islam Mohamed Ibrahim, Enterococcus faecium from chicken feces improves chicken immune response and alleviates Salmonella infections: a pilot study, Journal of Animal Science, Volume 101, 2023, skad016, https://doi.org/10.1093/jas/skad016

  11. Thirugnanasambantham, K., Nisha, S.N., Mandal, A.K.A. (2023). Novel Secondary Metabolites in Tea and Their Biological Role in Communicable and Noncommunicable Human Diseases. In: Kumar, N., S. Singh, R. (eds) Biosynthesis of Bioactive Compounds in Medicinal and Aromatic Plants. Food Bioactive Ingredients. Springer, Cham. https://doi.org/10.1007/978-3-031-35221-8_13

  12. Nirmala, N.S., Krishnan, N.B., Vivekanandan, V., Thirugnanasambantham, K. (2023). Anti-inflammatory Potential of Lead Compounds and Their Derivatives from Medicinal Plants. In: Arunachalam, K., Yang, X., Puthanpura Sasidharan, S. (eds) Bioprospecting of Tropical Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-031-28780-0_50

2022

  1. Kaliyamoorthy, V., Jacop, J.P., Thirugnanasambantham, K., Ibrahim H-IM ., Kandhasamy S. The synergic impact of lignin and Lactobacillus plantarum on DSS-induced colitis model via regulating CD44 and miR 199a alliance. World J Microbiol Biotechnol 38, 233 (2022). https://doi.org/10.1007/s11274-022-03424-z

  2. Ahmed EA, Abu Zahra H, Ammar RB, Mohamed ME, Ibrahim H-IM. Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules. Molecules. 2022; 27(23):8354. https://doi.org/10.3390/molecules27238354

  3. Almansour ZH, Ibrahim H-IM, Hamad RS, Abd El-Moaty HI. Phenolic-Compound-Rich Opuntia littoralis Ethyl Acetate Extract Relaxes Arthritic Symptoms in Collagen-Induced Mice Model via Bone Morphogenic Markers. Nutrients. 2022; 14(24):5366. https://doi.org/10.3390/nu14245366

  4. Khalil HE, Abdelwahab MF, Ibrahim H-IM, AlYahya KA, Altaweel AA, Alasoom AJ, Burshed HA, Alshawush MM, Waz S (2022). Cichoriin, a Biocoumarin, Mitigates Oxidative Stress and Associated Adverse Dysfunctions on High-Fat Diet-Induced Obesity in Rats. Life; 12(11):1731. https://doi.org/10.3390/life12111731

  5. Khalil, H.E.; Abdelwahab,M.F.; Ibrahim, H.-I.M.; AlYahya,K.A.; Mohamed, A.A.; Radwan, A.S.;Waz, S (2022). Mechanistic Insights into theAmeliorative Effect of Cichoriin onDiabetic Rats—Assisted with an InSilico Approach. Molecules, 27,7192. https://doi.org/10.3390/molecules27217192

  6. Ibrahim H-IM, Thangavelu M, Khalifa A (2022). Honey-Propolis-Engineered Collagen Peptides as Promising Wound-Healing Matrix in Mouse Model. Molecules. 27(20):7090. https://doi.org/10.3390/molecules27207090

  7. Harikrishnan P, Arayambath B, Jayaraman V.K, Ekambaram K, Ahmed E.A, Senthilkumar P, Ibrahim HM, Sundaresan A and Thirugnanasambantham K* (2022). Thidiazuron, a phenyl?urea cytokinin, inhibits ergosterol synthesis and attenuates biofilm formation of Candida albicans. World J Microbiol Biotechnol. 38:224. doi: 10.1007/s11274-022-03410-5

  8. Khalil HE, Abdelwahab MF, Emeka PM, Badger-Emeka LI, Ahmed A-SF, Anter AF, Abdel Hafez SMN, AlYahya KA, Ibrahim H-IM, Thirugnanasambantham K, Matsunami K, Ibrahim Selim AH (2022). Brassica oleracea L. var. botrytis Leaf Extract Alleviates Gentamicin-Induced Hepatorenal Injury in Rats—Possible Modulation of IL-1? and NF-?B Activity Assisted with Computational Approach. Life. 12(9):1370. https://doi.org/10.3390/life12091370

  9. Balthazar JD, Soosaimanickam MP, Emmanuel C, Thirugnanasambantham Krishnaraj, Sheikh A, Alghafis SF, Ibrahim HM (2022). 8-Hydroxyquinoline a natural chelating agent from Streptomyces spp. inhibits A549 lung cancer cell lines via BCL2/STAT3 regulating pathways. World J Microbiol Biotechnol. 38(10):182. doi: 10.1007/s11274-022-03368-4

  10. Ahmed EA, Alkuwayti MA, Ibrahim H-IM. Atropine Is a Suppressor of Epithelial–Mesenchymal Transition (EMT) That Reduces Stemness in Drug-Resistant Breast Cancer Cells. International Journal of Molecular Sciences. 2022; 23(17):9849. https://doi.org/10.3390/ijms23179849

  11. Rajendran, B., Manickam, V., Tamizhselvi, R., PrabhuDass, J. F., Iyer, S. K., Thirugnanasambantham, K., & Ibrahim, H.I.M. (2022). Azabicyclononane derivative downregulates the P38 MAP-kinase pathway in colon cancer through apoptosis. Chemical Biology Letters, 9(4), 369

  12. Bharanidharan R,Thirugnanasambantham K, Ibidhi R,Baik M, Kim TH, Lee Y and Kim KH (2022) Metabolite Profile, RuminalMethane Reduction, and Microbiome Modulating Potential of Seeds of Pharbitis nil. Front. Microbiol. 13:892605. doi: 10.3389/fmicb.2022.892605

  13. Khalil, H.E., Abdelwahab M.F., Emeka, P.M., Badger-Emeka,L.I., Thirugnanasambantham, K., Ibrahim, H.-I.M., Naguib, S.M.,Matsunami, K., Abdel-Wahab, N.M.Ameliorative Effect of Ocimum forskolei Benth on Diabetic, Apoptotic, and Adipogenic Biomarkers ofDiabetic Rats and 3T3-L1 Fibroblasts Assisted by In Silico Approach. Molecules 2022, 27, 2800. https://doi.org/10.3390/molecules27092800

  14. Khalifa, A., Sheikh, A.,Ibrahim, H.I.M. Bacillus amyloliquefaciens Enriched Camel Milk Attenuated Colitis Symptoms inMice Model. Nutrients 2022, 14, 1967. https://doi.org/10.3390/nu14091967

  15. Ibrahim, HI.M., Ahmed, E.A., Alzahrani, A.M. et al. (2022). Swertiamarin ameliorates inflammation and oxidative damage in autoimmune encephalomyelitis mouse model. Appl Biol Chem 65, 19. https://doi.org/10.1186/s13765-022-00682-1

  16. Maheswari, R.U., Thirugnanasambantham, K., Mondal, A. et al. (2022). Enzymatic hydrolysis of structurally upgraded lignocellulosic biomass with the aid of humic acid: a case study in a membrane integrated bioreactor. Environ Dev Sustain (2022). https://doi.org/10.1007/s10668-022-02233-6

  17. Khalil, H.E.; Ibrahim,H.-I.M.; Darrag, H.M.; Matsunami, K (2022).Insight into Analysis of Essential Oilfrom Anisosciadium LanatumBoiss.—Chemical Composition,Molecular Docking, and Mitigationof Hepg2 Cancer Cells throughApoptotic Markers. Plants, 11,66. https://doi.org/10.3390/plants11010066

  18. Khalil, H.E.; Ibrahim,H.-I.M.; Ahmed, E.A.; Emeka, P.M.;Alhaider, I.A (2022). Orientin, aBio-Flavonoid from Trigonella hamosaL., Regulates COX-2/PGE-2 in A549Cell Lines via miR-26b and miR-146a.Pharmaceuticals, 15, 154.https://doi.org/10.3390/ph15020154

  19. Kumar, P.S., Nattudurai, G., Islam, V.I.H. et al. (2022). The effects of some essential oils on Alternaria alternata, a post-harvest phyto-pathogenic fungus in wheat by disrupting ergosterol biosynthesis. Phytoparasitica. https://doi.org/10.1007/s12600-021-00970-4

  20. Khalil HE, Ibrahim H-IM, El-Fass KA, Akrawi SH, Morsy MA. Orientin Alleviates Liver Inflammation via Downregulation of ZEB-2/PTEN Markers—Hepatic Stellate Cells Approach. Applied Sciences. 2022; 12(5):2725. https://doi.org/10.3390/app12052725

2021

  1. Bharanidharan R†, Thirugnanasambantham K†, Ibidhi R, Bang G, Jang SS, Baek YC, Kim HK and Moon YH (2021). Effects of Dietary Protein Concentration on Lipid Metabolism Gene Expression and Fatty Acid Composition in 18–23-Month-Old Hanwoo Steers. Animals, 11: 3378. https://doi.org/10.3390/ani11123378

  2. Hairul Islam MI, AlZahrani A, Hanieh H, Emad AA and K. Thirugnanasambantham (2021). MicroRNA-7188-5p and miR-7235 regulates Multiple Sclerosis in an experimental mouse model. Molecular Immunology, 139: 157-167. (https://doi.org/10.1016/j.molimm.2021.07.002).

  3. Ibrahim HM, Ismail MB, Ammar RB, Ahmed EA. Thidiazuron suppresses breast cancer via targeting miR-132 and dysregulation of the PI3K-Akt signaling pathway mediated by the miR-202-5p-PTEN axis. Biochem Cell Biol. 2021 Jun;99(3):374-384. doi: 10.1139/bcb-2020-0377.

  4. Emad A Ahmed, Hairul-Islam Mohamed Ibrahim, and Hany Ezzat Khalil (2021). Pinocembrin Reduces Arthritic Symptoms in Mouse Model via Targeting Sox4 Signaling Molecules. Journal of Medicinal Food, 24(3) doi.org/10.1089/jmf.2020.4862

  5. Rajaraman Bharanidharan, Chang Hyun Lee, Krishnaraj Thirugnanasambantham, Ridha Ibidhi, Yang Won Woo, Hong-Gu Lee, Jong Geun Kim, Kyoung Hoon Kim (2021). Feeding Systems and Host Breeds Influence Ruminal Fermentation, Methane Production, Microbial Diversity and Metagenomic Gene Abundance. Frontiers in Microbiology, 12: doi: 10.3389/fmicb.2021.70108

2020

  1. Lorina I. Badger-Emeka*, Promise Madu Emeka, Krishnaraj Thirugnanasambantham and Hairul Islam M. Ibrahim (2020). Anti-Allergic Potential of Cinnamaldehyde via the Inhibitory Effect of Histidine Decarboxylase (HDC) Producing Klebsiella pneumonia. Molecules, 25(23), 5580; https://doi.org/10.3390/molecules25235580

  2. Promise M. Emeka, Lorina I. Badger-Emeka, Hairul-Islam M. Ibrahim, Krishnaraj Thirugnanasambantham and Jamal Hussen (2020). Inhibitory Potential of Mangiferin on Glucansucrase Producing Streptococcus mutans Biofilm in Dental Plaque. Applied Sciences 10(22), 8297; https://doi.org/10.3390/app10228297.

  3. Hairul-Islam Mohamed Ibrahim*, Hossam M. Darrag, Mohammed Refdan Alhajhoj and Hany Ezzat Khalil (2020). Biomolecule from Trigonella stellata from Saudi Flora to Suppress Osteoporosis via Osteostromal Regulations. Plants, 9(11), 1610; https://doi.org/10.3390/plants9111610.

  4. Thirugnanasambantham, K., Prabu, G. & Mandal, A.K.A. Synergistic effect of cytokinin and gibberellins stimulates release of dormancy in tea (Camellia sinensis (L.) O. Kuntze) bud. Physiol Mol Biol Plants 26, 1035–1045 (2020). https://doi.org/10.1007/s12298-020-00786-2


2019

  1. Raj Christian SD, Thirugnanasambantham K, Islam MIH, Sudalaimuthu MK, Sundaram S, Ashok G, Senthilkumar V, Muralidaran S, Subramanian S. Identification of Expressed miRNAs in Human Rheumatoid Arthritis Using Computational Approach - Discovery of a New miR-7167 from Human. Microrna. 2019;8(2):147-154. doi: 10.2174/2211536608666181204111438. PMID: 30514198.

  2. Senthil Kumar V, Kumaresan S, Tamizh MM, Hairul Islam MI, Thirugnanasambantham K. Anticancer potential of NF-?B targeting apoptotic molecule "flavipin" isolated from endophytic Chaetomium globosum. Phytomedicine. 2019 Aug;61:152830. doi: 10.1016/j.phymed.2019.152830.

  3. Harikrishnan P, Islam H, Sivasamy A. Biocompatibility Studies of Nanoengineered Polycaprolactone and Nanohydroxyapatite Scaffold for Craniomaxillofacial Bone Regeneration. J Craniofac Surg. 2019 Jan;30(1):265-269. doi: 10.1097/SCS.0000000000004857.